The Browns will also be missing starting linebacker Barkevious Mingo, who missed practice this week with a shoulder injury.
Cameron, who caught 80 passes for 917 yards and seven touchdowns last season, hurt his shoulder during training camp and then re-injured last week after making a 47-yard reception against Pittsburgh. Cameron did not practice this week.
Jabaal Sheard will start in place of Mingo, a first-round draft pick in 2013.
As expected, Browns running back Ben Tate is out with a sprained knee. Rookie Terrance West will start in his place. West rushed for 100 yards last week.
The only notable lineup change for the Saints is fullback Austin Johnson starting for Erik Lorig, who has an ankle injury.